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Brainstem dysfunctions in Rett syndrome

Episodes of Abnormal Spontaneous Brainstem Activations (ASBA) are exaggerated and simultaneous large increases in cardiac vagal tone, cardiac sensitivity to baroreflex and arterial blood pressure in a "Brainstem Storm". Feeble breathers who have in addition a co-existing hypoxia and hypercapnoea (high level of carbon dioxide in the blood) are predisposed to brainstem storms. The large increases in cardiac vagal tone carry the risk of cardiac arrest.

:: Brainstem Shutdown

:: Brainstem Epilepsy

:: Non-epileptic vacant spells

Julu, P.O.O (2001). The central autonomic disturbance in Rett syndrome. In: Kerr, A. and Witt Engerstrom, I (eds) Rett Disorder and the Developing Brain. Oxford University Press, Oxford, pp132-181.
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